Abstract
Hybrid antibiotics mederrhodins A and B were produced by a recombinant strain consisting of the medermycin-producing Streptomyces sp. strain AM7161 containing part of the gene clusters for actinorhodin biosynthesis of Streptomyces coelicolor A3(2). Mederrhodin A has a hydroxyl group at the C-6 position of the medermycin molecule, and mederrhodin B is dihydromederrhodin A. The antimicrobial activity of mederrhodin A resembled that of medermycin. Mederrhodin B was almost devoid of antimicrobial activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / biosynthesis*
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Anti-Bacterial Agents / pharmacology
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Chemical Phenomena
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Chemistry, Physical
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Fermentation
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Genetic Engineering
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Microbial Sensitivity Tests
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Naphthoquinones / biosynthesis
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Naphthoquinones / pharmacology
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Quinone Reductases / analysis
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Quinone Reductases / isolation & purification
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Recombination, Genetic
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Streptomyces / genetics
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Streptomyces / metabolism*
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Transformation, Genetic
Substances
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Anti-Bacterial Agents
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Naphthoquinones
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mederrhodin B
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mederrhodin A
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Quinone Reductases
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isochromanequinone reductase