The Gro3p factor: Restoring NAD+/NADH homeostasis to ameliorate mitochondrial disease

Divakar S Mithal; Navdeep S Chandel

doi:10.1016/j.cmet.2021.09.006

The Gro3p factor: Restoring NAD+/NADH homeostasis to ameliorate mitochondrial disease

Cell Metab. 2021 Oct 5;33(10):1905-1907. doi: 10.1016/j.cmet.2021.09.006.

Authors

Divakar S Mithal¹, Navdeep S Chandel²

Affiliations

¹ Department of Neurology, Ann and Robert H. Lurie Children's Hospital, Chicago, IL 60611, USA; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
² Department of Medicine, Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: nav@northwestern.edu.

PMID: 34614406
DOI: 10.1016/j.cmet.2021.09.006

Abstract

Leigh syndrome, a mitochondrial disease, can be modeled in mice with a deficiency in mitochondrial complex I that results in a decreased NAD+/NADH ratio. In this issue of Cell Metabolism, Liu et al. (2021) identify glycerol-3-phosphate (Gro3P) biosynthesis as a method for regenerating cytosolic NAD+ to ameliorate pathology in this mitochondrial disease model.

Publication types

Comment

MeSH terms

Animals
Cytosol / metabolism
Homeostasis
Mice
Mitochondria
Mitochondrial Diseases* / metabolism
NAD* / metabolism

Substances

NAD

Grants and funding

P01 AG049665/AG/NIA NIH HHS/United States