Regulation of glycolysis and cancer cell proliferation by PKM2 citrullination

Sébastien Coassolo; Irwin Davidson

doi:10.1080/23723556.2021.1927446

Regulation of glycolysis and cancer cell proliferation by PKM2 citrullination

Mol Cell Oncol. 2021 Jun 4;8(4):1927446. doi: 10.1080/23723556.2021.1927446. eCollection 2021.

Authors

Sébastien Coassolo^{1

2

3

4}, Irwin Davidson^{1

2

3

4}

Affiliations

¹ Equipe Labélisée Ligue Contre le Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch Cedex, France.
² Centre National de la Recherche Scientifique, UMR7104. Illkirch, France.
³ Institut National de la Santé et de la Recherche Médicale, U1258. Illkirch, France.
⁴ Université de Strasbourg, Strasbourg, France.

Abstract

Conversion of peptidyl-arginine to peptidyl citrulline, known as citrullination, is a post-translational protein modification catalyzed by the PADI (Protein Arginine Deiminase) family of enzymes. PADI1 and PADI3 catalyze citrullination of arginine 106 in the glycolytic enzyme pyruvate kinase M2 modulating its allosteric regulation, glycolysis and cancer cell proliferation.

Keywords: NuRD complex; allosteric regulation; chromatin; melanoma; protein arginine deiminase.

Grants and funding

This work was supported by institutional grants from the Centre National de la Recherche Scientifique, the Institut National de la Santé et de la Recherche Médicale, the Université de Strasbourg, the Association pour la Recherche contre le Cancer (CR, contract number PJA 20181208268), the Ligue Nationale contre le Cancer, the Institut National du Cancer, the ANR-10-LABX-0030-INRT French state fund through the Agence Nationale de la Recherche under the frame programme Investissements d’Avenir labelled ANR-10-IDEX-0002-02. ID is an ‘équipe labellisée’ of the Ligue Nationale contre le Cancer. SC was supported by a fellowship from the Ligue Nationale contre le Cancer.