Nutrients in the fate of pluripotent stem cells

Vivian Lu; Irena J Roy; Michael A Teitell

doi:10.1016/j.cmet.2021.09.013

Nutrients in the fate of pluripotent stem cells

Cell Metab. 2021 Nov 2;33(11):2108-2121. doi: 10.1016/j.cmet.2021.09.013. Epub 2021 Oct 12.

Authors

Vivian Lu¹, Irena J Roy², Michael A Teitell³

Affiliations

¹ Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
² Developmental and Stem Cell Biology, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
³ Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, California NanoSystems Institute, and Broad Center for Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: mteitell@mednet.ucla.edu.

Abstract

Pluripotent stem cells model certain features of early mammalian development ex vivo. Medium-supplied nutrients can influence self-renewal, lineage specification, and earliest differentiation of pluripotent stem cells. However, which specific nutrients support these distinct outcomes, and their mechanisms of action, remain under active investigation. Here, we evaluate the available data on nutrients and their metabolic conversion that influence pluripotent stem cell fates. We also discuss key questions open for investigation in this rapidly expanding area of increasing fundamental and practical importance.

Keywords: development; differentiation; fate; metabolism; nutrients; pluripotent stem cell.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Cell Differentiation
Cell Lineage
Mammals
Nutrients
Pluripotent Stem Cells*

Abstract

Publication types

MeSH terms

Grants and funding