Cellular senescence in the tumor microenvironment and context-specific cancer treatment strategies

Tadahito Yasuda; Hideo Baba; Takatsugu Ishimoto

doi:10.1111/febs.16231

Cellular senescence in the tumor microenvironment and context-specific cancer treatment strategies

FEBS J. 2023 Mar;290(5):1290-1302. doi: 10.1111/febs.16231. Epub 2021 Oct 24.

Authors

Tadahito Yasuda^{1

2}, Hideo Baba^{2

3}, Takatsugu Ishimoto^{1

2}

Affiliations

¹ Gastrointestinal Cancer Biology, International Research Center for Medical Sciences (IRCMS), Kumamoto University, Japan.
² Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Japan.
³ Center for Metabolic Regulation of Healthy Aging, Faculty of Life Sciences, Kumamoto University, Japan.

PMID: 34653317
DOI: 10.1111/febs.16231

Abstract

Cellular senescence in cancer development is known to have tumor-suppressive and tumor-promoting roles. Recent studies have revealed numerous molecular mechanisms of senescence followed by senescence-associated secretory phenotype induction and showed the significance of senescence on both sides. Cellular senescence in stromal cells is one of the reasons for therapeutic resistance in advanced cancer; thus, it is an inevitable phenomenon to address while seeking an effective cancer treatment strategy. This review summarizes the molecular mechanisms regarding cellular senescence, focusing on the dual roles played by senescence, and offers some direction toward successful treatments targeting harmful senescent cells.

Keywords: CAFs; SASP; epigenome; senescence; senolytic drug.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cellular Senescence
Humans
Neoplasms* / drug therapy
Neoplasms* / genetics
Tumor Microenvironment*