Sharing is caring: The benefits of distributing protein aggregates among microglial networks

Vera I Wiersma; Magdalini Polymenidou

doi:10.1016/j.neuron.2021.10.008

Sharing is caring: The benefits of distributing protein aggregates among microglial networks

Neuron. 2021 Oct 20;109(20):3228-3230. doi: 10.1016/j.neuron.2021.10.008.

Authors

Vera I Wiersma¹, Magdalini Polymenidou²

Affiliations

¹ Department of Quantitative Biomedicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
² Department of Quantitative Biomedicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. Electronic address: magdalini.polymenidou@uzh.ch.

PMID: 34672979
DOI: 10.1016/j.neuron.2021.10.008

Abstract

The trafficking of protein aggregates through neural circuitries causes adverse outcomes, including propagation of pathology and toxicity in neurodegenerative diseases. In a recent issue of Cell, Scheiblich et al. (2021) describe an advantageous aggregate-sharing strategy in microglial networks that nurtures α-synuclein-loaded members back to health.

Keywords: microglia; mitochondria; neurodegenerative disorders; prion-like spreading; protein aggregation; α-synuclein.

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MeSH terms

Humans
Microglia*
Neurodegenerative Diseases*
Protein Aggregates
alpha-Synuclein

Substances

Protein Aggregates
alpha-Synuclein