The lung microbiome in end-stage Lymphangioleiomyomatosis

Julie Ng; Gustavo Pacheco-Rodriguez; Lesa Begley; Yvonne J Huang; Sergio Poli; Mark A Perrella; Ivan O Rosas; Joel Moss; Souheil El-Chemaly

doi:10.1186/s12931-021-01873-y

The lung microbiome in end-stage Lymphangioleiomyomatosis

Respir Res. 2021 Oct 26;22(1):277. doi: 10.1186/s12931-021-01873-y.

Authors

Affiliations

¹ Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
² Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
³ Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
⁴ Department of Internal Medicine, Mount Sinai Medical Center, Miami, FL, USA.
⁵ Department of Medicine, Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX, USA.
⁶ Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA. Sel-chemaly@bwh.harvard.edu.

^# Contributed equally.

Abstract

Lymphangioleiomyomatosis (LAM) is a progressive cystic lung disease with mortality driven primarily by respiratory failure. Patients with LAM frequently have respiratory infections, suggestive of a dysregulated microbiome. Here we demonstrate that end-stage LAM patients have a distinct microbiome signature compared to patients with end-stage chronic obstructive pulmonary disease.

Keywords: Lymphangioleiomyomatosis; Microbiome.

Publication types

Comparative Study
Letter

MeSH terms

Disease Progression
Dysbiosis
Humans
Lung / microbiology*
Lung Diseases, Fungal / diagnosis
Lung Diseases, Fungal / microbiology
Lymphangioleiomyomatosis / diagnosis
Lymphangioleiomyomatosis / microbiology*
Microbiota*
Pulmonary Disease, Chronic Obstructive / diagnosis
Pulmonary Disease, Chronic Obstructive / microbiology*
Respiratory Tract Infections / diagnosis
Respiratory Tract Infections / microbiology*
Ribotyping

Abstract

Publication types

MeSH terms

Grants and funding