Dendritic cells shape TCF1+CD8+ progenitor T cell heterogeneity

Sonia Ghilas; Lisa A Mielke

doi:10.1016/j.it.2021.10.013

Dendritic cells shape TCF1⁺CD8⁺ progenitor T cell heterogeneity

Trends Immunol. 2021 Dec;42(12):1063-1065. doi: 10.1016/j.it.2021.10.013. Epub 2021 Nov 10.

Authors

Sonia Ghilas¹, Lisa A Mielke²

Affiliations

¹ Olivia Newton-John Cancer Research Institute, La Trobe University School of Cancer Medicine, Heidelberg, Victoria, Australia. Electronic address: sonia.ghilas@onjcri.org.au.
² Olivia Newton-John Cancer Research Institute, La Trobe University School of Cancer Medicine, Heidelberg, Victoria, Australia. Electronic address: lisa.mielke@onjcri.org.au.

PMID: 34774417
DOI: 10.1016/j.it.2021.10.013

Abstract

In two elegant studies, Tyler Jacks' group and colleagues unveil crucial interactions between dendritic cells and TCF1⁺CD8⁺ progenitor T cells, shaping their heterogeneity and offering potential to design new putative cancer immunotherapies and vaccines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

CD8-Positive T-Lymphocytes*
Dendritic Cells
Hepatocyte Nuclear Factor 1-alpha* / genetics
Humans
Immunotherapy

Substances

Hepatocyte Nuclear Factor 1-alpha