Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype

Simone Di Franco; Giorgio Stassi

doi:10.1080/23723556.2021.1986343

Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype

Mol Cell Oncol. 2021 Oct 18;8(5):1986343. doi: 10.1080/23723556.2021.1986343. eCollection 2021.

Authors

Simone Di Franco¹, Giorgio Stassi¹

Affiliation

¹ Department of Surgical Oncological and Stomatological Sciences (DICHIRONS), University of Palermo, Palermo, Italy.

Abstract

Colon cancer progression is among the risks that increase with obesity. We have recently unveiled the molecular mechanism by which adipose tissue-released molecules, HGF and IL-6, make colorectal cancer (CRC) cells acquiring mesenchymal traits. Targeting of adipose-derived factors abrogate the metastatic potential of CRC stem cells (CR-CSCs) in obese patients.

Grants and funding

AIRC under 5 × 1000 (9979); AIRC IG (21445); PRIN 2017WNKSLR.