Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans

Cell Metab. 2022 Jan 4;34(1):1-2. doi: 10.1016/j.cmet.2021.12.002. Epub 2021 Dec 10.

Abstract

Zickler et al. describe SARS-CoV-2 RNA in post-mortem samples of human adipose tissue. In the hamster model, SARS-CoV-2 propagation in adipose tissue leads to specific changes in lipid metabolism, which are reflected in lipidome patterns of hamster and human plasma.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / metabolism*
  • Adipose Tissue / virology
  • Animals
  • COVID-19 / metabolism
  • COVID-19 / virology*
  • Cricetinae
  • Female
  • Humans
  • Lipid Metabolism*
  • Liver / metabolism*
  • Liver / virology
  • Lung / metabolism*
  • Lung / virology
  • Male
  • SARS-CoV-2 / isolation & purification*
  • Virus Replication*