Abstract
Important colorectal cancer (CRC) studies in 2021, including a new standard of care for first-line treatment of MSI-H–dMMR metastatic CRC, single-cell and spatial analysis of primary tumours and investigations of diet in preclinical models of cancer initiation, have provided novel insights into the CRC immune microenvironment.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antibodies, Monoclonal, Humanized / therapeutic use
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Antineoplastic Agents, Immunological / therapeutic use
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Colorectal Neoplasms / immunology
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Colorectal Neoplasms / pathology
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Colorectal Neoplasms / therapy*
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Humans
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Immunotherapy*
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Tumor Microenvironment / physiology*
Substances
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Antibodies, Monoclonal, Humanized
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Antineoplastic Agents, Immunological
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pembrolizumab