Experimental murine models of brainstem gliomas

Shuting Ni; Rujing Chen; Kaili Hu

doi:10.1016/j.drudis.2021.12.016

Experimental murine models of brainstem gliomas

Drug Discov Today. 2022 May;27(5):1218-1235. doi: 10.1016/j.drudis.2021.12.016. Epub 2021 Dec 23.

Authors

Shuting Ni¹, Rujing Chen², Kaili Hu³

Affiliations

¹ Murad Research Center for Modernized Chinese Medicine, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
² Murad Research Center for Modernized Chinese Medicine, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
³ Murad Research Center for Modernized Chinese Medicine, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: kaili-hu@163.com.

PMID: 34954326
DOI: 10.1016/j.drudis.2021.12.016

Abstract

As an intractable central nervous system (CNS) tumor, brainstem glioma (BG) is one of the leading causes of pediatric death by brain tumors. Owing to the risk of surgical resection and the little improvement in survival time after radiotherapy and chemotherapy, there is an urgent need to find reliable model systems to better understand the regional pathogenesis of the brainstem and improve treatment strategies. In this review, we outline the evolution of BG murine models, and discuss both their advantages and limitations in drug discovery.

Keywords: Brainstem glioma; Diffuse intrinsic pontine glioma; Experimental murine model.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain Stem Neoplasms* / pathology
Brain Stem Neoplasms* / surgery
Child
Disease Models, Animal
Glioma* / drug therapy
Glioma* / pathology
Humans
Mice