The chemical biology of ubiquitin

George M Burslem

doi:10.1016/j.bbagen.2021.130079

The chemical biology of ubiquitin

Biochim Biophys Acta Gen Subj. 2022 Mar;1866(3):130079. doi: 10.1016/j.bbagen.2021.130079. Epub 2021 Dec 29.

Author

George M Burslem¹

Affiliation

¹ Department of Biochemistry and Biophysics, Department of Cancer Biology and Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA. Electronic address: George.Burslem@Pennmedicine.upenn.edu.

Abstract

This mini-review will cover the various chemical biology approaches employed to prepare and modulate ubiquitin chains and the ubiquitin-proteasome system. Emphasis will be given to the biochemistry and chemical biology of poly-ubiquitin chain preparation as a tool to elucidate its roles in biological systems as well as the hijacking of the ubiquitin proteasome system using heterobifunctional compounds to induce intracellular ubiquitination.

Keywords: Chemical biology; Protein synthesis; Ubiquitin.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Ubiquitin*

Substances

Ubiquitin

Grants and funding

R35 GM142505/GM/NIGMS NIH HHS/United States