Aging is a process by which basic cellular functions and tissue homeostasis start to decline and organs become progressively dysfunctional. Although aging was once considered irreversible, the concept of the elixir of youth or rejuvenation has been in the history for centuries. In fact, recent scientific studies now show the existence of alternative strategies to delay aging. Here, we discuss how different signaling pathways, a variety of cell types and molecules can contribute to delay aging. In addition, we will define recently described rejuvenation strategies, with an emphasis on the potential for extracellular vesicles (EV).
Keywords: SASP; Senescence; aging; extracellular vesicles; intercellular communication; rejuvenation.