Learning from natural variation across the proteomes of single cells

PLoS Biol. 2022 Jan 5;20(1):e3001512. doi: 10.1371/journal.pbio.3001512. eCollection 2022 Jan.

Abstract

Biological functions arise from protein interactions, which are reflected in the natural variation of proteome configurations across individual cells. Emerging single-cell proteomics methods may decode this variation and empower inference of biological mechanisms with minimal assumptions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Proteome / metabolism*
  • Proteomics / methods*
  • Single-Cell Analysis*

Substances

  • Proteome