Palmitic acid: Enabling the tumor's nerves

H Furkan Alkan; Patricia Altea-Manzano; Sarah-Maria Fendt

doi:10.1016/j.cmet.2021.12.015

Palmitic acid: Enabling the tumor's nerves

Cell Metab. 2022 Jan 4;34(1):7-9. doi: 10.1016/j.cmet.2021.12.015.

Authors

H Furkan Alkan¹, Patricia Altea-Manzano¹, Sarah-Maria Fendt²

Affiliations

¹ Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium.
² Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium. Electronic address: sarah-maria.fendt@kuleuven.be.

PMID: 34986339
DOI: 10.1016/j.cmet.2021.12.015

Abstract

Diet can influence tumor aggressiveness. Recently in Nature, a study by Pascual et al. provided evidence that dietary palmitic acid induces an epigenetic memory by modulating particular histone methylation marks in cancer cells. This allows cancer cells to activate extracellular matrix secretion from Schwann cells of the tumor microenvironment, which ultimately potentiates metastasis initiation.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Epigenomics
Humans
Methylation
Neoplasms*
Palmitic Acid*
Tumor Microenvironment

Substances

Palmitic Acid