Palladium-Catalyzed Regioselective Arylalkenylation of Ynamides

Org Lett. 2022 Feb 25;24(7):1524-1529. doi: 10.1021/acs.orglett.2c00197. Epub 2022 Feb 14.

Abstract

A cationic palladium-catalyzed arylalkenylation of ynamides is presented. The putative keteniminium arylpalladium intermediate likely dictates the regioselective carbopalladation of the ynamide to form a vinylpalladium species. The capture of this complex by the olefin yields linear conjugated β-alkenyl aminodienes (especially with trans selectivity). The transformation features a broad scope with labile functional group tolerance and makes 42 unusual molecular scaffolds with structural diversity. DFT studies provide valuable insights into the reaction mechanism.

Publication types

  • Research Support, Non-U.S. Gov't