Impact of Latent Tuberculosis on Diabetes

Burcu Tepekule; Katharina Kusejko; Marius Zeeb; Philip E Tarr; Alexandra Calmy; Manuel Battegay; Hansjakob Furrer; Matthias Cavassini; Enos Bernasconi; Julia Notter; Huldrych F Günthard; Johannes Nemeth; Roger D Kouyos; Swiss HIV Cohort Study

doi:10.1093/infdis/jiac054

Impact of Latent Tuberculosis on Diabetes

J Infect Dis. 2022 Jun 15;225(12):2229-2234. doi: 10.1093/infdis/jiac054.

Authors

Burcu Tepekule^{1

2}, Katharina Kusejko^{1

2}, Marius Zeeb^{1

2}, Philip E Tarr³, Alexandra Calmy⁴, Manuel Battegay⁵, Hansjakob Furrer⁶, Matthias Cavassini⁷, Enos Bernasconi⁸, Julia Notter⁹, Huldrych F Günthard¹, Johannes Nemeth¹, Roger D Kouyos^{1

2}; Swiss HIV Cohort Study

Collaborators

Swiss HIV Cohort Study:
I Abela, K Aebi-Popp, A Anagnostopoulos, M Battegay, E Bernasconi, D L Braun, H C Bucher, A Calmy, M Cavassini, A Ciuffi, G Dollenmaier, M Egger, L Elzi, J Fehr, J Fellay, H Furrer, C A Fux, H F Günthard, A Hachfeld, D Haerry, B Hasse, H H Hirsch, M Hoffmann, I Hösli, M Huber, C R Kahlert, L Kaiser, O Keiser, T Klimkait, R D Kouyos, H Kovari, K Kusejko, G Martinetti, B Martinez de Tejada, C Marzolini, K J Metzner, N Müller, J Nemeth, D Nicca, P Paioni, G Pantaleo, M Perreau, A Rauch, P Schmid, R Speck, M Stöckle, P Tarr, A Trkola, G Wandeler, S Yerly

Affiliations

¹ Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
² Institute of Medical Virology, University of Zurich, Zurich, Switzerland.
³ Department of Medicine and Division of Infectious Diseases and Hospital Epidemiology, Kantonsspital Baselland, University of Basel, Bruderholz, Switzerland.
⁴ Division of Infectious Diseases, University Hospital Geneva, University of Geneva, Geneva, Switzerland.
⁵ Division of Infectious Diseases and Hospital Hygiene, University Hospital Basel, University of Basel, Basel, Switzerland.
⁶ Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland.
⁷ Division of Infectious Diseases, University Hospital, Lausanne, Switzerland.
⁸ Division of Infectious Diseases, Regional Hospital Lugano, Lugano, Switzerland.
⁹ Cantonal Hospital St Gallen, Division of Infectious Diseases and Hospital Epidemiology, St Gallen, Switzerland.

PMID: 35172332
DOI: 10.1093/infdis/jiac054

Abstract

While an increased risk of active and latent tuberculosis infection (LTBI) in people with type-2 diabetes (DM) has been demonstrated, it is less well characterized whether LTBI is associated with an increased risk of developing DM. We investigated the link between LTBI and DM in people living with HIV in the Swiss HIV Cohort Study via time-dependent Cox proportional hazards models. We found that LTBI significantly increased the risk of developing DM (HR = 1.47), which was robust across different adjustment and censoring techniques. Our results thus suggest that LTBI may be associated with an increased risk of developing DM.

Keywords: heterologous immunity; inflammatory diseases; innate immunity; latent tuberculosis; low-grade inflammation; type-2 diabetes mellitus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cohort Studies
Diabetes Mellitus, Type 2* / complications
HIV Infections* / complications
Humans
Latent Tuberculosis* / complications
Latent Tuberculosis* / epidemiology

Grants and funding

177499/SNSF_/Swiss National Science Foundation/Switzerland