Autophagy-Inflammation Interplay During Infection: Balancing Pathogen Clearance and Host Inflammation

Yuqian Pang; Lanxi Wu; Cheng Tang; Hongna Wang; Yongjie Wei

doi:10.3389/fphar.2022.832750

Autophagy-Inflammation Interplay During Infection: Balancing Pathogen Clearance and Host Inflammation

Front Pharmacol. 2022 Feb 22:13:832750. doi: 10.3389/fphar.2022.832750. eCollection 2022.

Authors

Yuqian Pang^{1

2}, Lanxi Wu^{1

2}, Cheng Tang^{1

2}, Hongna Wang^{1

2

3}, Yongjie Wei^{1

2

4}

Affiliations

¹ Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China.
² Key Laboratory for Cell Homeostasis and Cancer Research of Guangdong Higher Education Institutes, Guangzhou, China.
³ GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University, Guangzhou, China.
⁴ State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.

Abstract

Inflammation is an essential immune response of the host against infections but is often over-activated, leading to a variety of disorders. Autophagy, a conserved degradation pathway, also protects cells by capturing intracellular pathogens that enter the cell and transporting them to the lysosome for clearance. Dysfunctional autophagy is often associated with uncontrolled inflammatory responses during infection. In recent years, more and more research has focused on the crosstalk between autophagy and inflammation. In this paper, we review the latest research advances in this field, hoping to gain insight into the mechanisms by which the body balances autophagy and inflammation in infections and how this mechanism can be used to fight infections better.

Keywords: autophagy; bacteria; infection; inflammasome; inflammation; microbial; virus.

Publication types

Review