Body temperature is a more important modulator of lifespan than metabolic rate in two small mammals

Abstract

The relationships between metabolic rate, body temperature (T_b), body composition and ageing are complex, and not fully resolved. In particular, T_b and metabolic rate often change in parallel, making disentangling their effects difficult. Here we show that in both sexes of mice and hamsters exposure to a temperature of 32.5 °C leads to a reduced lifespan, coincident with lowered metabolic rate and elevated T_b with no change in body composition. We exploit the unique situation that when small mammals are exposed to hot ambient temperatures their T_b goes up, at the same time that their metabolic rate goes down, allowing us to experimentally separate the impacts of T_b and metabolic rate on lifespan. The impact of ambient temperature on lifespan can be reversed by exposing the animals to elevated heat loss by forced convection, which reverses the effect on T_b but does not affect metabolic rate, demonstrating the causal effect of T_b on lifespan under laboratory conditions for these models. The impact of manipulations such as calorie restriction that increase lifespan may be mediated via effects on T_b, and measuring T_b may be a useful screening tool for putative therapeutics to extend the human lifespan.