Abstract
Macroautophagy/autophagy is a conserved eukaryotic process to mediate the degradation of cell organelles and protein aggregates, which participates in a variety of cellular responses, including immune signal transduction. KDM4D functions as an important histone demethylase to regulate gene transcription by inhibiting histone H3K9 trimethylation. Whether autophagy epigenetically regulates the immune response via modulating the stability and activity of KDM4D remains largely unclear. Recently, we identified TRIM14 (tripartite motif-containing 14) as an epigenetic regulator, which recruits USP14 and BRCC3 to form a regulatory complex, and promotes an inflammation response through inhibiting OPTN-mediated autophagic degradation of KDM4D.
Keywords:
Autophagy; KDM4D; TRIM14; epigenetic regulation; inflammation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Autophagy* / genetics
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Deubiquitinating Enzymes / metabolism
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Humans
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Inflammation
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Intracellular Signaling Peptides and Proteins / metabolism
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Jumonji Domain-Containing Histone Demethylases* / genetics
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Jumonji Domain-Containing Histone Demethylases* / metabolism
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Methylation
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Protein Processing, Post-Translational
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Tripartite Motif Proteins / metabolism
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Ubiquitin Thiolesterase / metabolism
Substances
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Intracellular Signaling Peptides and Proteins
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TRIM14 protein, human
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Tripartite Motif Proteins
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USP14 protein, human
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Jumonji Domain-Containing Histone Demethylases
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KDM4D protein, human
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BRCC3 protein, human
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Deubiquitinating Enzymes
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Ubiquitin Thiolesterase
Grants and funding
This work was supported by the National Key R&D Program of China under Grant 2020YFA0908700, the National Natural Science Foundation of China (92042303, 31870862), and the Guangdong Basic and Applied Basic Research Foundation (2020B1515120090).