Cardiovascular Inflammaging: Mechanisms and Translational Aspects

Cells. 2022 Mar 16;11(6):1010. doi: 10.3390/cells11061010.

Abstract

Aging is one of the major non-reversible risk factors for several chronic diseases, including cancer, type 2 diabetes, dementia, and cardiovascular diseases (CVD), and it is a key cause of multimorbidity, disability, and frailty (decreased physical activity, fatigue, and weight loss). The underlying cellular mechanisms are complex and consist of multifactorial processes, such as telomere shortening, chronic low-grade inflammation, oxidative stress, mitochondrial dysfunction, accumulation of senescent cells, and reduced autophagy. In this review, we focused on the molecular mechanisms and translational aspects of cardiovascular aging-related inflammation, i.e., inflammaging.

Keywords: cardiac inflammaging; microbiome; mitochondrial homeostasis; vascular senescence.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cellular Senescence*
  • Diabetes Mellitus, Type 2* / complications
  • Humans
  • Inflammation / etiology
  • Lung