Impact of IDH1 c.315C>T SNP on Outcomes in Acute Myeloid Leukemia: A Propensity Score-Adjusted Cohort Study

Elizabeth M Corley; Moaath K Mustafa Ali; Hanan Alharthy; Kathryn A F Kline; Danielle Sewell; Jennie Y Law; Seung Tae Lee; Sandrine Niyongere; Vu H Duong; Maria R Baer; Ashkan Emadi

doi:10.3389/fonc.2022.804961

Impact of IDH1 c.315C>T SNP on Outcomes in Acute Myeloid Leukemia: A Propensity Score-Adjusted Cohort Study

Front Oncol. 2022 Mar 18:12:804961. doi: 10.3389/fonc.2022.804961. eCollection 2022.

Authors

Elizabeth M Corley¹, Moaath K Mustafa Ali^{2

3}, Hanan Alharthy³, Kathryn A F Kline^{2

3}, Danielle Sewell⁴, Jennie Y Law^{2

3}, Seung Tae Lee^{2

3}, Sandrine Niyongere^{2

3}, Vu H Duong^{2

3}, Maria R Baer^{2

3}, Ashkan Emadi^{2

3

4

5}

Affiliations

¹ School of Medicine, University of Maryland, Baltimore, Baltimore, MD, United States.
² Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, Baltimore, MD, United States.
³ Department of Medicine, School of Medicine, University of Maryland, Baltimore, Baltimore, MD, United States.
⁴ Translational Genomics Laboratory, Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, Baltimore, MD, United States.
⁵ Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, Baltimore, MD, United States.

Abstract

Acute myeloid leukemia (AML) is the common type of acute leukemia in adults. Definitive prognostic significance of variants of unknown significance lacks for many commonly mutated genes, including the isocitrate dehydrogenase 1 (IDH1) synonymous single nucleotide polymorphism (SNP) variant c.315C>T. In this retrospective cohort study of 248 AML patients at the University of Maryland Greenebaum Comprehensive Cancer Center, we show that the IDH1 c.315C>T SNP, previously reported to be associated with poor prognosis by other studies with conflicting data, does not confer worse prognosis, with a median overall survival (OS) of 17.1 months compared to 15.1 months for patients without this SNP (P=0.57). The lack of negative effect on prognosis by IDH1 SNP c.315C>T is consistent with the absence of amino acid alteration (p.Gly105Gly).

Keywords: AML; IDH1 c.315C>T SNP; Myeloid mutations; prognosis; survival.