The aim of the study was to identify and analyze the top 50 influential articles showing historical developments and current research activity published during January 1979 - December 2019 in the European Review for Medical and Pharmacological Sciences journal. Electronic search was conducted using Scopus database to retrieve publications in the journal of European Review for Medical and Pharmacological Sciences journal during January 1979 - December 2019. The papers ranked in ascending order with citation count ≥47. Furthermore frequent first and co-authors; number of funding sources reported; study type and authors affiliated institute and country of origin was identified in these highly cited articles. Of the highly cited studies published, qualitative and quantitative studies were published in predominance (n=47) trailed by reviews studies (n=6). All the top 50 cited articles were contributed by single nations without any collaborations (n=53). The universities contributing major amount of top cited articles included Nanjing Medical University and Sapienza University of Rome (n=7) respectively, followed by Capital Medical University (n=3). China was the nation majorly contributed for top cited articles. The use of pharmacological therapies for different medical conditions published in European Review for Medical and Pharmacological Sciences journal during the last 40 years were extensively explored and reported.