What Can We Learn from Synaptic Connectivity Maps about Cerebellar Internal Models?

Cerebellum. 2023 Jun;22(3):468-474. doi: 10.1007/s12311-022-01392-6. Epub 2022 Apr 7.

Abstract

The cerebellum is classically associated with fine motor control, motor learning, and timing of actions. However, while its anatomy is well described and many synaptic plasticity have been identified, the computation performed by the cerebellar cortex is still debated. We, here, review recent advances on how the description of the functional synaptic connectivity between granule cells and Purkinje cells support the hypothesis that the cerebellum stores internal models of the body coordinates. We propose that internal models are specific of the task and of the locomotor context of each individual.

Keywords: cerebellum; internal models; sensorimotor adaptation; synaptic transmission.

Publication types

  • Review

MeSH terms

  • Cerebellar Cortex
  • Cerebellum*
  • Neuronal Plasticity
  • Neurons
  • Purkinje Cells*