Breakage in breakage-fusion-bridge cycle: an 80-year-old mystery

Thomas M Guérin; Stéphane Marcand

doi:10.1016/j.tig.2022.03.008

Breakage in breakage-fusion-bridge cycle: an 80-year-old mystery

Trends Genet. 2022 Jul;38(7):641-645. doi: 10.1016/j.tig.2022.03.008. Epub 2022 Apr 6.

Authors

Thomas M Guérin¹, Stéphane Marcand²

Affiliations

¹ Université Paris-Saclay, Université de Paris, Inserm, CEA, Institut de Biologie François Jacob, iRCM, UMR Stabilité Génétique Cellules Souches et Radiations, Fontenay-aux-Roses, France; Current address: Chromosome Segregation Laboratory, The Francis Crick Institute, London, UK.
² Université Paris-Saclay, Université de Paris, Inserm, CEA, Institut de Biologie François Jacob, iRCM, UMR Stabilité Génétique Cellules Souches et Radiations, Fontenay-aux-Roses, France. Electronic address: stephane.marcand@cea.fr.

PMID: 35397934
DOI: 10.1016/j.tig.2022.03.008

Abstract

2021 marked the 80th anniversary of Barbara McClintock's pioneering article on the breakage-fusion-bridge (BFB) cycle. Of the three steps of the BFB cycle, breakage remains the least understood despite its major contribution to mutagenesis. We discuss recent findings shedding light on how chromatin bridges break in yeast and animal cells.

Keywords: chromosome; cytokinesis; dicentric; genome instability; oncogenesis; telomere.

Publication types

Biography
Historical Article

MeSH terms

Cell Cycle / genetics*
Chromosomes*
Cytogenetics / history*
Genomic Instability
History, 20th Century
Saccharomyces cerevisiae* / genetics
Telomere

Personal name as subject

Barbara McClintock