Establishing spatial control over TORC1 signaling

Oliver Schmidt; Mariana E G de Araujo

doi:10.1083/jcb.202203136

Establishing spatial control over TORC1 signaling

J Cell Biol. 2022 May 2;221(5):e202203136. doi: 10.1083/jcb.202203136. Epub 2022 Apr 9.

Authors

Oliver Schmidt¹, Mariana E G de Araujo¹

Affiliation

¹ Institute of Cell Biology, Biocenter Innsbruck, Medical University of Innsbruck, Innsbruck, Austria.

Abstract

Target-of-rapamycin complex 1 resides on lysosomes/vacuoles and additionally on signaling endosomes. Gao et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202109084) set out to define the molecular identity of signaling endosomes, along with players required for the formation and maintenance of this endosomal subpopulation.

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MeSH terms

Endosomes*
Lysosomes
Mechanistic Target of Rapamycin Complex 1* / genetics
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins*
Signal Transduction*
Transcription Factors*
Vacuoles*

Substances

Saccharomyces cerevisiae Proteins
TORC1 protein complex, S cerevisiae
Transcription Factors
Mechanistic Target of Rapamycin Complex 1