SnapShot: Regulation and biology of PGC-1α

Cell. 2022 Apr 14;185(8):1444-1444.e1. doi: 10.1016/j.cell.2022.03.027.

Abstract

The peroxisome proliferator-activated receptor γ coactivator-1α (Ppargc1a) gene encodes several PGC-1α isoforms that regulate mitochondrial bioenergetics and cellular adaptive processes. Expressing specific PGC-1α isoforms in mice can confer protection in different disease models. This SnapShot summarizes how regulation of Ppargc1a transcription, splicing, translation, protein stability, and activity underlies its multifaceted functions. To view this SnapShot, open or download the PDF.

MeSH terms

  • Animals
  • Biology
  • Energy Metabolism
  • Gene Expression Regulation*
  • Mice
  • Mitochondria* / genetics
  • Mitochondria* / metabolism
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / genetics
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism

Substances

  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • Protein Isoforms