To die or not to die - How mitochondrial processes affect lifespan of Podospora anserina

Abstract

The filamentous ascomycete Podospora anserina is a well-established model system to study organismic aging. Its senescence syndrome has been investigated for more than fifty years and turned out to have a strong mitochondrial etiology. Several different mitochondrial pathways were demonstrated to affect aging and lifespan. Here, we present an update of the literature focusing on the cooperative interplay between different processes.

Keywords: Aging; Lifespan; Mitochondria; Mitochondrial proteases; Podospora anserina; Respiratory chain.