Role of exosomal competitive endogenous RNA (ceRNA) in diagnosis and treatment of malignant tumors

Bioengineered. 2022 May;13(5):12156-12168. doi: 10.1080/21655979.2022.2073130.

Abstract

Malignant tumors are a threat to human health, thus it is critical to better understand the mechanism of tumor occurrence and development and to find key therapeutic targets. Competitive endogenous RNA (ceRNA) is a type of RNA molecule that includes mRNA of coding-protein, pseudogenes, long non-coding RNA (lncRNA), and circular RNA (circRNA) etc. It is created through a competitive combination of common small RNA (miRNA) and has an inhibitory effect on mRNA translation. ceRNA regulate the post transcriptional expression of genes by competitively binding to common microRNAs (miRNAs).Studies have shown that cernas are involved in tumor cell proliferation, invasion and migration, drug resistance, angiogenesis, as well as tumor immunity, and so on, affecting the progression of tumor development. This article reviews the reported roles of exosomal ceRNA in the diagnosis and treatment of malignant tumors and the mechanisms underlying these.

Keywords: ceRNA; diagnosis; exosomal; malignant tumor; treatment.

Publication types

  • Review

MeSH terms

  • Exosomes* / genetics
  • Humans
  • MicroRNAs / genetics
  • Neoplasms* / diagnosis
  • Neoplasms* / genetics
  • RNA, Circular* / genetics
  • RNA, Long Noncoding* / genetics
  • RNA, Long Noncoding* / metabolism
  • RNA, Messenger / genetics

Substances

  • MicroRNAs
  • RNA, Circular
  • RNA, Long Noncoding
  • RNA, Messenger

Grants and funding

This work was supported by grants from the Natural Science Foundation of Zhejiang Provincial (grant nos. LY19H160014, LY20H130001, LQ21H130001), Medical and HealthResearch Project of Zhejiang Province (grant nos. 2019ZD018, 2021KY307), Ningbo Health Branding Subject Fund. (grant no. PPXK2018-02), Ningbo Natural Science Foundation (grant nos. 2018A610361, 2019A610319, 202003N4239), the Ningbo ‘Technology Innovation 2025’ Major Special Project (grant nos. 2018B10015, 2020Z097), and the Key Project of Teaching and Research of Ningbo University (grant no. JYXMXZD2021033).