CeCaFLUX: the first web server for standardized and visual instationary 13C metabolic flux analysis

Bioinformatics. 2022 Jun 27;38(13):3481-3483. doi: 10.1093/bioinformatics/btac341.

Abstract

Summary: The number of instationary 13C-metabolic flux (INST-MFA) studies grows every year, making it more important than ever to ensure the clarity, standardization and reproducibility of each study. We proposed CeCaFLUX, the first user-friendly web server that derives metabolic flux distribution from instationary 13C-labeled data. Flux optimization and statistical analysis are achieved through an evolutionary optimization in a parallel manner. It can visualize the flux optimizing process in real-time and the ultimate flux outcome. It will also function as a database to enhance the consistency and to facilitate sharing of flux studies.

Availability and implementation: CeCaFLUX is freely available at https://www.cecaflux.net, the source code can be downloaded at https://github.com/zhzhd82/CeCaFLUX.

Supplementary information: Supplementary data are available at Bioinformatics online.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbon Isotopes / metabolism
  • Metabolic Flux Analysis*
  • Models, Biological*
  • Reproducibility of Results
  • Software

Substances

  • Carbon-13
  • Carbon Isotopes