Identification of an amplified, highly expressed gene in a human glioma

Science. 1987 Apr 3;236(4797):70-3. doi: 10.1126/science.3563490.

Abstract

A gene, termed gli, was identified that is amplified more than 50-fold in a malignant glioma. The gene is expressed at high levels in the original tumor and its derived cell line and is located at chromosome 12 position (q13 to q14.3). The gli gene is a member of a select group of cellular genes that are genetically altered in primary human tumors.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cell Line
  • Chromosomes, Human, Pair 12*
  • Cloning, Molecular
  • DNA, Neoplasm / genetics*
  • Gene Amplification*
  • Gene Expression Regulation
  • Glioma / genetics*
  • Humans
  • RNA, Messenger / genetics
  • RNA, Neoplasm / genetics

Substances

  • DNA, Neoplasm
  • RNA, Messenger
  • RNA, Neoplasm