PRODH2-Mediated Proline Metabolism Boosts CAR T-cell Effector Function

Cancer Discov. 2022 Jun 2;12(6):1405. doi: 10.1158/2159-8290.CD-RW2022-054.

Abstract

Overexpression of PRODH2 augments CAR T-cell proliferation, effector function, and memory phenotype.

MeSH terms

  • Humans
  • Lymphocyte Activation*
  • Phenotype
  • Proline* / metabolism
  • T-Lymphocytes / metabolism

Substances

  • Proline