Engineered KRAS G12D-Reactive T Cells Show Promise in Pancreatic Cancer

Cancer Discov. 2022 Aug 5;12(8):1833. doi: 10.1158/2159-8290.CD-RW2022-103.

Abstract

T cells with engineered KRAS G12D-specific TCRs mediated regression of metastases in a patient with pancreatic cancer.

Publication types

  • Comment

MeSH terms

  • Carcinoma, Pancreatic Ductal* / genetics
  • Carcinoma, Pancreatic Ductal* / pathology
  • Humans
  • Pancreatic Neoplasms* / genetics
  • Pancreatic Neoplasms* / pathology
  • Proto-Oncogene Proteins p21(ras) / genetics
  • Receptors, Antigen, T-Cell
  • T-Lymphocytes / pathology

Substances

  • KRAS protein, human
  • Receptors, Antigen, T-Cell
  • Proto-Oncogene Proteins p21(ras)