Resolving mutational signatures in cancer development

Cancer Cell. 2022 Jul 11;40(7):711-713. doi: 10.1016/j.ccell.2022.05.011. Epub 2022 Jun 9.

Abstract

In a recent Science study, an advanced mutational signature analysis was performed on an unprecedentedly large set of cancer whole-genome sequences across multiple organs. This work introduces a computational framework to identify common and rare mutational signatures and provides insights into their biological interpretation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Genome, Human*
  • Humans
  • Mutation
  • Neoplasms* / genetics