Ubiquitinating the way to T cell metabolism

J Cell Biol. 2022 Jul 4;221(7):e202206006. doi: 10.1083/jcb.202206006. Epub 2022 Jun 13.

Abstract

In this issue, Harris et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202203095) show that phosphofructokinase is a substrate for ubiquitination by Fbxo7, a key protein in the ubiquitination pathway. Their findings point to a new interplay between metabolic enzyme degradation in the regulation of T cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • F-Box Proteins* / metabolism
  • Humans
  • Phosphofructokinases* / metabolism
  • T-Lymphocytes* / metabolism
  • Ubiquitination*

Substances

  • F-Box Proteins
  • FBXO7 protein, human
  • Phosphofructokinases