Radiotherapy-induced metabolic hallmarks in the tumor microenvironment

Anjali Mittal; Minal Nenwani; Itisam Sarangi; Abhinav Achreja; Theodore S Lawrence; Deepak Nagrath

doi:10.1016/j.trecan.2022.05.005

Radiotherapy-induced metabolic hallmarks in the tumor microenvironment

Trends Cancer. 2022 Oct;8(10):855-869. doi: 10.1016/j.trecan.2022.05.005. Epub 2022 Jun 22.

Authors

Anjali Mittal¹, Minal Nenwani², Itisam Sarangi³, Abhinav Achreja³, Theodore S Lawrence⁴, Deepak Nagrath⁵

Affiliations

¹ Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
² Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
³ Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
⁴ Rogel Cancer Center, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address: tsl@med.umich.edu.
⁵ Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI, 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address: dnagrath@umich.edu.

PMID: 35750630
DOI: 10.1016/j.trecan.2022.05.005

Abstract

Radiation is frequently administered for cancer treatment, but resistance or remission remains common. Cancer cells alter their metabolism after radiotherapy to reduce its cytotoxic effects. The influence of altered cancer metabolism extends to the tumor microenvironment (TME), where components of the TME exchange metabolites to support tumor growth. Combining radiotherapy with metabolic targets in the TME can improve therapy response. We review the metabolic rewiring of cancer cells following radiotherapy and put these observations in the context of the TME to describe the metabolic hallmarks of radiotherapy in the TME.

Keywords: DNA repair; fatty acid metabolism; metabolic reprogramming; radioresistance; redox metabolism; tumor microenvironment.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Antineoplastic Agents* / pharmacology
Humans
Neoplasms* / therapy
Tumor Microenvironment

Substances

Antineoplastic Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding