ESCRTed resistance to T cell attack

Simona Maria Migliano; Harald Stenmark

doi:10.1016/j.it.2022.06.007

ESCRTed resistance to T cell attack

Trends Immunol. 2022 Aug;43(8):598-600. doi: 10.1016/j.it.2022.06.007. Epub 2022 Jul 6.

Authors

Simona Maria Migliano¹, Harald Stenmark²

Affiliations

¹ Centre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway.
² Centre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway; Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Faculty of Medicine, N-7491 Trondheim, Norway. Electronic address: stenmark@ulrik.uio.no.

PMID: 35810056
DOI: 10.1016/j.it.2022.06.007

Abstract

Cytotoxic T cells kill target cells such as cancer cells by making pores in their plasma membrane through which toxic enzymes are secreted. Ritter and colleagues now show that cancer cells can actively remove such pores via the action of endosomal sorting complex required for transport (ESCRT) proteins, thereby counteracting CD8⁺ T cell-mediated killing.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Endosomal Sorting Complexes Required for Transport* / metabolism
Endosomes* / metabolism
Humans
Protein Transport

Substances

Endosomal Sorting Complexes Required for Transport