Is PSD-95 entangled in the side effects of antidepressants?

Katarzyna Stachowicz

doi:10.1016/j.neuint.2022.105391

Is PSD-95 entangled in the side effects of antidepressants?

Neurochem Int. 2022 Oct:159:105391. doi: 10.1016/j.neuint.2022.105391. Epub 2022 Jul 9.

Author

Katarzyna Stachowicz¹

Affiliation

¹ Department of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna, 12, 31-343, Kraków, Poland. Electronic address: stachow@if-pan.krakow.pl.

PMID: 35817245
DOI: 10.1016/j.neuint.2022.105391

Abstract

PSD-95 is a component and a building block of an excitatory synapse. PSD-95 is a specialized protein that is part of a "combination lock" system responsible for plastic events at the synapse, such as receptor expression, which consequently induces changes in the PSD structure and thus affects synaptic plasticity. The possible involvement of PSD-95 in antidepressant side effects related to cognitive function and psychosis will be considered. An attempt will be made to trace the sequence of events in the proposed mechanism leading to these disorders, focusing mainly on NMDA receptors. Understanding the mechanisms of action of compounds with antidepressant potential may facilitate the design of safer drugs.

Keywords: Antidepressants; Cognition; Excitatory synapse; PSD-95; Psychosis; Side effects.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Antidepressive Agents / adverse effects
Disks Large Homolog 4 Protein / metabolism
Neuronal Plasticity
Receptors, N-Methyl-D-Aspartate* / metabolism
Synapses* / metabolism

Substances

Antidepressive Agents
Disks Large Homolog 4 Protein
Receptors, N-Methyl-D-Aspartate