Arginine Depletion plus GCN2 Inhibition Sensitizes HCC Cells to Senolytic Therapies

Cancer Discov. 2022 Sep 2;12(9):2015. doi: 10.1158/2159-8290.CD-RW2022-131.

Abstract

Combined arginine depletion, GCN2 kinase inhibition, and senolytic therapy reduces HCC growth.

MeSH terms

  • Arginine
  • Carcinoma, Hepatocellular* / drug therapy
  • Carcinoma, Hepatocellular* / genetics
  • Eukaryotic Initiation Factor-2
  • Humans
  • Liver Neoplasms* / drug therapy
  • Protein Serine-Threonine Kinases
  • Senotherapeutics

Substances

  • Eukaryotic Initiation Factor-2
  • Senotherapeutics
  • Arginine
  • Protein Serine-Threonine Kinases