Generation of human induced iPSC KUMi003-A from acute promyelocytic leukemia (APL) M3

Ji-Hea Kim; Ka-Won Kang; Byung-Hyun Lee; Young Park; Byung-Soo Kim

doi:10.1016/j.scr.2022.102861

Generation of human induced iPSC KUMi003-A from acute promyelocytic leukemia (APL) M3

Stem Cell Res. 2022 Aug:63:102861. doi: 10.1016/j.scr.2022.102861. Epub 2022 Jul 9.

Authors

Ji-Hea Kim¹, Ka-Won Kang², Byung-Hyun Lee², Young Park², Byung-Soo Kim³

Affiliations

¹ Institute of Stem Cell Research, Korea University College of Medicine, Seoul, South Korea; Department of Biomedical and Science, Graduate School of Medicine, Korea University, Seoul, South Korea.
² Department of Internal Medicine, Korea University Medical School Hospital, Seoul, South Korea.
³ Institute of Stem Cell Research, Korea University College of Medicine, Seoul, South Korea; Department of Biomedical and Science, Graduate School of Medicine, Korea University, Seoul, South Korea; Department of Internal Medicine, Korea University Medical School Hospital, Seoul, South Korea.

PMID: 35905670
DOI: 10.1016/j.scr.2022.102861

Abstract

Acute promyelocytic leukemia (APL) M3 is an acute myeloid leukemia (AML) subtype and is characterized by the chromosomal translocation t(15;17)(p22;q11), which results in the fusion of the promyelocytic gene (PML) at 15q22 with the retinoic acid α-receptor gene (RARA) at 17q21. We generated an induced pluripotent stem cell line "KUMi003-A" from an APL M3 patient that is pluripotent and can differentiate into the three germ layers. This iPSC line will be useful as a disease model to investigate disease mechanisms specific to APL M3.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Induced Pluripotent Stem Cells*
Leukemia, Promyelocytic, Acute* / genetics
Oncogene Proteins, Fusion / genetics
Receptors, Retinoic Acid
Translocation, Genetic

Substances

Oncogene Proteins, Fusion
Receptors, Retinoic Acid