Induction of Cross-Reacting Antibodies Against the COVID-19 by BCG Vaccination in the Mouse Model

Curr Microbiol. 2022 Jul 30;79(9):275. doi: 10.1007/s00284-022-02971-w.

Abstract

It was reported that tuberculosis and BCG vaccination are potential tools for reducing the burden of COVID-19, mainly through the non-specific trained immunity. We have investigated whether BCG vaccination is able to induce cross-reacting antibodies against the SARS-CoV-2. We have tested the induced humoral immune responses against the SARS-CoV-2 Spike in the mouse model, after either BCG or rabies DNA-based vaccination alone or in Prime/Boost approach to COVID-19 DNA-based vaccination. We have demonstrated that BCG vaccination alone was able to induce cross-reacting antibodies to SARS-CoV-2 Spike. It can also boost the antibody response induced by a COVID-19 DNA-based vaccination. Hence, both BCG and latent tuberculosis infection can explain the lower burden of COVID-19 in developing countries, not only through the trained immunity but also by inducing cross-reacting antibodies. Furthermore, with the emergence of different COVID-19 variants, or eventually other Betacoronaviruses, the use of BCG vaccination can help against immune escapes of the current vaccines.

MeSH terms

  • Animals
  • Antibodies, Viral
  • BCG Vaccine
  • COVID-19* / prevention & control
  • Disease Models, Animal
  • Mice
  • SARS-CoV-2
  • Vaccination

Substances

  • Antibodies, Viral
  • BCG Vaccine

Supplementary concepts

  • SARS-CoV-2 variants