Outrunning obesity with Lac-Phe?

Jens Lund; Christoffer Clemmensen; Thue W Schwartz

doi:10.1016/j.cmet.2022.07.007

Outrunning obesity with Lac-Phe?

Cell Metab. 2022 Aug 2;34(8):1085-1087. doi: 10.1016/j.cmet.2022.07.007.

Authors

Jens Lund¹, Christoffer Clemmensen², Thue W Schwartz³

Affiliations

¹ Novo Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
² Novo Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: chc@sund.ku.dk.
³ Novo Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: tws@sund.ku.dk.

PMID: 35921816
DOI: 10.1016/j.cmet.2022.07.007

Abstract

Lactate released from skeletal muscle during high-intensity exercise gives rise to a surge in circulating lactate-derived pseudo-dipeptide metabolites including N-lactoyl-phenylalanine (Lac-Phe). In a recent Nature paper, Li et al. use genetic and pharmacological evidence to now propose Lac-Phe to be an "exercise hormone" that suppresses appetite and obesity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Exercise / physiology
Humans
Lactic Acid*
Muscle, Skeletal
Obesity
Phenylalanine*

Substances

Lactic Acid
Phenylalanine