PI3K-AKT Inhibits PANK4 to Promote De Novo Synthesis of Coenzyme A

Cancer Discov. 2022 Oct 5;12(10):2229. doi: 10.1158/2159-8290.CD-RW2022-140.

Abstract

AKT inhibits the metabolic enzyme PANK4 to promote the de novo synthesis of coenzyme A (CoA).

MeSH terms

  • Coenzyme A*
  • Humans
  • Phosphatidylinositol 3-Kinases*
  • Phosphotransferases (Alcohol Group Acceptor) / metabolism*
  • Proto-Oncogene Proteins c-akt

Substances

  • Phosphotransferases (Alcohol Group Acceptor)
  • pantothenate kinase
  • Proto-Oncogene Proteins c-akt
  • Coenzyme A