Systems biochemistry to "deorphanize" human mitochondrial proteome

Francois Miros; Ran Liu; Hongying Shen

doi:10.1016/j.molcel.2022.07.005

Systems biochemistry to "deorphanize" human mitochondrial proteome

Mol Cell. 2022 Aug 4;82(15):2735-2737. doi: 10.1016/j.molcel.2022.07.005.

Authors

Francois Miros¹, Ran Liu¹, Hongying Shen²

Affiliations

¹ Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA; Systems Biology Institute, Yale West Campus, West Haven, CT, USA.
² Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA; Systems Biology Institute, Yale West Campus, West Haven, CT, USA. Electronic address: hongying.shen@yale.edu.

PMID: 35931038
DOI: 10.1016/j.molcel.2022.07.005

Abstract

Rensvold, Shishkova, et al. (2022) apply an integrated systems biology approach spanning proteomics, lipidomics, and metabolomics to a collection of CRISPR knockout cells targeting 116 distinct human mitochondrial proteins, revealing new mitochondrial biology and guiding orphan disease diagnosis.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Humans
Lipidomics
Metabolomics
Proteome* / genetics
Proteome* / metabolism
Proteomics*
Systems Biology

Substances

Proteome

Grants and funding

R00 GM124296/GM/NIGMS NIH HHS/United States