DUB-le vision: snapshots of the proteasome during substrate processing

Helena M Schnell; John Hanna

doi:10.1016/j.tibs.2022.07.007

DUB-le vision: snapshots of the proteasome during substrate processing

Trends Biochem Sci. 2022 Nov;47(11):903-905. doi: 10.1016/j.tibs.2022.07.007. Epub 2022 Aug 10.

Authors

Helena M Schnell¹, John Hanna²

Affiliations

¹ Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
² Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. Electronic address: jwhanna@bwh.harvard.edu.

Abstract

Covalent modification by the small protein ubiquitin can target proteins for destruction by the proteasome, but the ubiquitin signal itself is recycled. Surprisingly, proteasomes contain three different deubiquitinating enzymes (DUBs). Recent work by Zhang and Zou et al. reveals how one of these enzymes, Usp14, regulates, and is regulated by, the proteasome.

Keywords: Rpn11; Ubp6; Usp14; proteasome; ubiquitin.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Deubiquitinating Enzymes / metabolism
Proteasome Endopeptidase Complex* / metabolism
Ubiquitin* / metabolism

Substances

Ubiquitin
Deubiquitinating Enzymes
Proteasome Endopeptidase Complex

Abstract

Publication types

MeSH terms

Substances

Grants and funding