Fission impossible: Mitochondrial dynamics direct muscle stem cell fates

Ji-Hyung Lee; Foteini Mourkioti

doi:10.1016/j.stem.2022.08.010

Fission impossible: Mitochondrial dynamics direct muscle stem cell fates

Cell Stem Cell. 2022 Sep 1;29(9):1287-1289. doi: 10.1016/j.stem.2022.08.010.

Authors

Ji-Hyung Lee¹, Foteini Mourkioti²

Affiliations

¹ Department of Orthopaedic Surgery, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA.
² Department of Orthopaedic Surgery, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA; Penn Institute for Regenerative Medicine, Musculoskeletal Regeneration Program, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA. Electronic address: fmour@pennmedicine.upenn.edu.

PMID: 36055187
DOI: 10.1016/j.stem.2022.08.010

Abstract

Muscle stem cells (MuSCs) exhibit different metabolic profiles depending on their activity, however the mechanisms by which mitochondria affect MuSC fate has been understudied. In this issue of Cell Stem Cell, Hong et al. (2022) and Baker et al. (2022) demonstrate that defects in mitochondrial dynamics hinder proper MuSC activation and impair muscle regeneration.

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MeSH terms

Mitochondrial Dynamics*
Muscle, Skeletal*
Myoblasts / metabolism