Dosimetric comparison between VMAT plans using the fast-rotating O-ring linac with dual-layer stacked MLC and helical tomotherapy for nasopharyngeal carcinoma

Abstract

Background: To compare the dosimetric profiles of volumetric modulated arc therapy (VMAT) plans using the fast-rotating O-ring linac (the Halcyon system) based on a dual-layer stacked multi-leaf collimator and helical tomotherapy (HT) for nasopharyngeal cancer (NPCa).

Methods: For 30 NPCa patients, three sets of RT plans were generated, under the same policy of contouring and dose constraints: HT plan; Halcyon VMAT plan with two arcs (HL_2arc); and Halcyon VMAT plan with four arcs (HL_4arc), respectively. The intended dose schedule was to deliver 67.2 Gy to the planning gross target volume (P-GTV) and 56.0 Gy to the planning clinical target volume (P-CTV) in 28 fractions using the simultaneously integrated boost concept. Target volumes and organ at risks dose metrics were evaluated for all plans. Normal tissue complication probabilities (NTCP) for esophagus, parotid glands, spinal cord, and brain stem were compared.

Results: The HT plan achieved the best dose homogeneity index for both P_GTV and P_CTV, followed by the HL_4arc and L_2arc plans. No significant difference in the dose conformity index (CI) for P_GTV was observed between the HT plan (0.80) and either the HL_2arc plan (0.79) or the HL_4arc plan (0.83). The HL_4arc plan showed the best CI for P_CTV (0.88), followed by the HL_2arc plan (0.83) and the HT plan (0.80). The HL_4arc plan (median, interquartile rage (Q1, Q3): 25.36 (22.22, 26.89) Gy) showed the lowest D_mean in the parotid glands, followed by the HT (25.88 (23.87, 27.87) Gy) and HL_2arc plans (28.00 (23.24, 33.99) Gy). In the oral cavity (OC) dose comparison, the HT (22.03 (19.79, 24.85) Gy) plan showed the lowest D_mean compared to the HL_2arc (23.96 (20.84, 28.02) Gy) and HL_4arc (24.14 (20.17, 27.53) Gy) plans. Intermediate and low dose regions (40-65% of the prescribed dose) were well fit to the target volume in HL_4arc, compared to the HT and HL_2arc plans. All plans met the dose constraints for the other OARs with sufficient dose margins. The between-group differences in the median NTCP values for the parotid glands and OC were < 3.47% and < 1.7% points, respectively.

Conclusions: The dosimetric profiles of Halcyon VMAT plans were comparable to that of HT, and HL_4arc showed better dosimetric profiles than HL_2arc for NPCa.

Keywords: Halcyon; IMRT; Nasopharyngeal cancer; Plan comparison; Tomotherapy; VMAT.