NCOA4: More than a receptor for ferritinophagy

J Cell Biol. 2022 Oct 3;221(10):e202209004. doi: 10.1083/jcb.202209004. Epub 2022 Sep 16.

Abstract

Liquid-liquid phase separation (LLPS) triages protein cargoes for autophagic degradation. In this issue, Ohshima et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202203102) demonstrate that the autophagy receptor NCOA4 interacts with ferritin particles to form liquid-like condensates via LLPS. The NCOA4-ferritin condensates are delivered to lysosomes for degradation via either canonical macroautophagy or endosomal microautophagy to maintain intracellular iron homeostasis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Autophagy* / genetics
  • Ferritins* / genetics
  • Ferritins* / metabolism
  • Iron* / metabolism
  • Lysosomes / genetics
  • Lysosomes / metabolism
  • Nuclear Receptor Coactivators* / genetics
  • Nuclear Receptor Coactivators* / metabolism

Substances

  • Nuclear Receptor Coactivators
  • Ferritins
  • Iron