The requirement for mitochondrial respiration in cancer varies with disease stage

Colin Sheehan; Alexander Muir

doi:10.1371/journal.pbio.3001800

The requirement for mitochondrial respiration in cancer varies with disease stage

PLoS Biol. 2022 Sep 23;20(9):e3001800. doi: 10.1371/journal.pbio.3001800. eCollection 2022 Sep.

Authors

Colin Sheehan¹, Alexander Muir¹

Affiliation

¹ Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois, United States of America.

Abstract

The roles for glycolytic and respiratory metabolism in supporting in vivo tumor growth in different contexts are not well understood. In this issue of PLOS Biology, a new study reveals that primary and metastatic tumors demonstrate divergent metabolic requirements.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Glycolysis
Humans
Mitochondria* / metabolism
Neoplasms* / metabolism
Respiration

Grants and funding

AM is supported the American Cancer Society (IRG-16-222-56), the University of Chicago Cancer Center Support Grant (P30 CA14599), the Pancreatic Cancer Action Network (2020 Career Development Award), the Brinson Foundation, the Cancer Research Foundation and the Ludwig Center for Metastasis Research. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.